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STATUS Current
FUND Life Sciences

Evelo Biosciences

Evelo Biosciences (Nasdaq:EVLO) is a clinical stage biotechnology company developing orally delivered product candidates that are designed to act on SINTAX™, the Small INTestinal AXis, with systemic therapeutic effects.  Cells in the small intestine are known to play a central role in governing the body’s immune, metabolic and neurological systems.

These orally delivered, room-temperature stable therapies are single strains of microbes selected for defined pharmacological properties.  They have been observed to have systemic dose-dependent effects, modulating multiple clinically validated pathways. Evelo Biosciences has also observed that specific microbes can down- or up-regulate immune responses throughout the body by acting on cells in the small intestine.

Evelo Biosciences has created an integrated platform to develop a range of oral biologics which harness this central role and the efficiency of their platform has allowed Evelo to produce, in a relatively short period of time, product candidates for a range of inflammatory diseases, including the treatment of COVID-19 and many cancers.

In 2019, the JIMCO Life Sciences Fund participated in a Series B post-IPO equity investment in Evelo, and in parallel, Abdul Latif Jameel Health agreed a strategic collaboration to develop and commercialize Evelo’s novel therapy EDP1815 – if approved by relevant health authorities – for inflammatory diseases including COVID-19 in select developing markets in the Middle East, Turkey, and Africa, serving over 1.7 billion people.

Series B (Post IPO Equity) Dec 2019
Post IPO Equity May 2022
FOUNDING TEAM
  • Noubar Afeyan
    Founder & CEO, Flagship Pioneering
  • David Berry
    General Partner, Flagship Pioneering
PARTNERS
  • Dr. Simba Gill, PhD
    CEO Evelo Biosciences
FOUNDED
website

Evelo currently has four product candidates in development: EDP1815, EDP1867, and EDP2939 for the treatment of inflammatory diseases, and EDP1908 for the treatment of cancer. Evelo is advancing additional product candidates in other disease areas.

Evelo’s therapies exert their effects by engaging with host immune cells as they pass through the small intestine. In a clinical study, they have been observed to be well tolerated, with limited systemic exposure and no observed colonization. The team at Evelo Biosciences believe that their product candidate’s ability to exert integrated effects on multiple pathways via convenient oral delivery drives their potential to impact diseases in ways not addressed by traditional and widely-used single-target therapies.

Dr. Simba Gill PhD

Chief Executive Officer Evelo Biosciences
Dr. Simba Gill, Ph.D. is President, Chief Executive Officer and a member of the Board of Directors of Evelo Biosciences since 2015.
 
Dr. Gill has served on the board of directors of Realm Therapeutics PLC since 2016, and as a Venture Partner at Flagship Pioneering, a life sciences innovation enterprise, since 2015.
 
JIMCO Life Sciences Fund recently caught-up with Simba for a fascinating insight into their breakthrough science and how this impacts health inclusivity for all.

 

News from our Portfolio Businesses

The brands and business in the JIMCO investment portfolio are making the news around the world as their transformational approach to global challenges is enabling all of us to take steps towards a more beautiful tomorrow.

You can catch-up with some of their latest headlines here:

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Evelo Biosciences

Today, we’re pleased to announce Evelo Biosciences has secured $79.2

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June is Alzheimer’s & Brain Awareness Month. Chronic inflammation of the nervous

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Evelo Biosciences

-> Here’s why Evelo aims to provide effective, safe, well-tolerated,

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Evelo Biosciences

NEW: Endpoints News details Evelo Biosciences securing $79.2M in new funding from

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Important note: these news items are links to external third-party content and will open in a new tab. These links are provided for your information only. JIMCO has, unless explicitly indicated otherwise, no control over the content of those sites or resources and has no rights in the content of those sites or in the resources. JIMCO assumes no responsibility for the content of websites linked on the JIMCO Website. Such links should not be interpreted as endorsement by JIMCO nor Abdul Latif Jameel of those linked websites therein.

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